plasma levels of anabolic hormones in suckling lambs are affected by late gestational nutrition
نویسندگان
چکیده
in this study, the effects of late gestational undernutrition (lgu) on plasma concentration of insulin-like growth factor 1 (igf-i), leptin, insulin and glucose in subsequent sucking lambs was investigated. ten twin-bearing ewes were fed either restrictedly (restricted) or adequately (control) during the last six weeks of gestation and were fed ad libitum after parturition. blood samples were taken from subsequent suckling lambs at birth day, 7, 17 and 35 days of age. the average growth rate of restricted lambs was significantly lower than control lambs (292±21 vs. 216±19 g/d) during first two weeks of suckling period. lambs in both groups were hypoglycemic (2.5±0.2 mmol/l) and had lowest level of leptin (0.6±0.08 ng/ml) at birth. plasma glucose and leptin increased sharply by 7 days of age to 5.9 ± 0.2 mmol/l and to 0.6±0.08 ng/ml respectively. late gestational undernutrition reduced plasma glucose in restricted (3.1±0.2 mmol/l) at birth but not in control lambs (2.1±0.3 mmol/l). plasma insulin was the highest at 7 days of age (0.9±0.08 ng/ml). restricted lambs had highly significant lower insulin values (0.6±0.1 vs. 1.3±0.1 ng/ml) and significantly higher ratio of glucose/insulin than control lambs. insulin-like growth factor i values at birth was not affected by lgu. however, during suckling period restricted lambs had lower igf-i than control lambs. in conclusion, lgu decreased insulin plasma concentration, changed the ratio of glucose to insulin, and decreased the concentration of igf-i in subsequent offspring. results also confirm the finding that circulating glucose rather than insulin is a determinant of leptin secretion in suckling lambs.
منابع مشابه
Plasma Levels of Anabolic Hormones in Suckling Lambs are Affected by Late Gestational Nutrition
In this study, the effects of late gestational undernutrition (LGU) on plasma concentration of insulin-like growth factor 1 (IGF-I), leptin, insulin and glucose in subsequent sucking lambs was investigated. Ten twin-bearing ewes were fed either restrictedly (Restricted) or adequately (Control) during the last six weeks of gestation and were fed ad libitum after parturition. Blood samples were t...
متن کاملProgramming of intermediate metabolism in young lambs affected by late gestational maternal undernourishment.
Effects of moderate maternal undernourishment during late gestation on the intermediary metabolism and maturational changes in young lambs were investigated. 20 twin-bearing sheep, bred to two different rams, were randomly allocated the last 6 wk of gestation to either a NORM diet [barley, protein supplement, and silage ad libitum approximately 15 MJ metabolizable energy (ME)/day] or a LOW diet...
متن کاملeffects of late gestational protein restriction on birth weight, growth rate and plasma concentrations of igf1, insulin, urea and glucose in suckling lambs
0
متن کاملScintigraphic evaluation of abomasal emptying rate in neonatal suckling lambs
Evaluation of gastric emptying rate using nuclear scintigraphy as the gold standard method has been studied in various animals, but there is no report in suckling lambs. The aim of this study was to develop a nuclear scintigraphic method to visualize and measure abomasal emptying rate by estimation of scintigraphic half emptying time (T1/2) in the live neonatal lamb. Five healthy, female Irania...
متن کاملOngoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.
OBJECTIVE To determine the relationship between serum P levels on the day of hCG administration and ongoing pregnancy rates. DESIGN Retrospective study. SETTING University-affiliated private IVF. PATIENT(S) A total of 2,458 couples undergoing IUI. INTERVENTION(S) Ovarian stimulation with human recombinant FSH. MAIN OUTCOME MEASURE(S) Ongoing pregnancy and miscarriage rates. RESULT(S...
متن کاملPituitary Thyrotropic Cells Are Affected by Steroid Hormones
Thyrotrophs are basophilic TSH hormone-producing cells occurring in pars distalis (pd) and pars tuberalis (pt) of the adenohypophysis. These cells are involved in the regulation of thyroid hormones secretion through the hypothalamic-pituitary-thyroid complex. Within the thyrotrope subsets other neuroendocrine peptides are co-localized with TSH hormonesecretogranins/chromogranins, a highly conse...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of applied animal scienceناشر: islamic azad university - rasht branch
ISSN 2251-628X
دوره 3
شماره 4 2015
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023